1-METHYL-6-OXO-2,3,5,6-TETRAHYDROINDOLE-5-SEMICARBAZONO-2-SULFONIC ACID SODIUM SALT 3 HYDRATE
Carbazochrome Sodium Sulfonate
CAS: 51460-26-5
Molecular Formula: C10H17N4NaO8S
1-METHYL-6-OXO-2,3,5,6-TETRAHYDROINDOLE-5-SEMICARBAZONO-2-SULFONIC ACID SODIUM SALT 3 HYDRATE - Names and Identifiers
| Name | Carbazochrome Sodium Sulfonate |
| Synonyms | adonatrihydrate CARBAZOCHROMESODIUMSULPHONATE CARBAZOCHROME SODIUM SULFONATE Carbazochrome Sodium Sulfonate adrenochromesulfonateac17trihydrate thyl-6-oxo-,monosodiumsalt,trihydrate CARBAZOCHROME SODIUM SULFONATE TRIHYDRATE (5E)-3-hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dione 5-semicarbazone sodium1-methyl-5-semicarbazono-6-oxo-2,3,5,6-tetrahydroindole-3-sulfonate sodium 5-(carbamoylhydrazono)-2,3,5,6-tetrahydro-1-methyl-6-oxo-1h-indole-2-sulphonate sodium (5Z)-5-(carbamoylhydrazono)-1-methyl-6-oxo-2,3,5,6-tetrahydro-1H-indole-2-sulfonate sodium (5E)-5-(carbamoylhydrazono)-1-methyl-6-oxo-2,3,5,6-tetrahydro-1H-indole-2-sulfonate 1-METHYL-6-OXO-2,3,5,6-TETRAHYDROINDOLE-5-SEMICARBAZONO-2-SULFONIC ACID SODIUM SALT 3 HYDRATE |
| CAS | 51460-26-5 |
| EINECS | 257-217-0 |
| InChI | InChI=1/C10H12N4O5S.Na/c1-14-7-4-8(15)6(12-13-10(11)16)2-5(7)3-9(14)20(17,18)19;/h2,4,9H,3H2,1H3,(H3,11,13,16)(H,17,18,19);/q;+1/p-1/b12-6- |
| InChIKey | HLFCZZKCHVSOAP-DAMYXMBDSA-M |
1-METHYL-6-OXO-2,3,5,6-TETRAHYDROINDOLE-5-SEMICARBAZONO-2-SULFONIC ACID SODIUM SALT 3 HYDRATE - Physico-chemical Properties
| Molecular Formula | C10H17N4NaO8S |
| Molar Mass | 376.32 |
| Melting Point | approximate 210℃(dec.) |
| Solubility | DMSO (Sparingly), Methanol (Slightly) |
| Appearance | Solid |
| Color | Yellow to Dark Orange |
| PH | pH (16g/l, 25℃) 5.0～6.0 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Stability | Hygroscopic, Moisture Sensitive, Temperature Sensitive |
| Physical and Chemical Properties | This product is orange-yellow crystalline powder; Odorless this product is soluble in hot water, slightly soluble in water, almost insoluble in ethanol or chloroform |
| Use | Blood System medicine for hemostasis |
| In vitro study | Carbazochrome(0.1-1 M) reverses the dysfunction of tryptase, thrombin and Kinin, which is enhanced by calcium ionophores such as ionomycin,A23187 or phorbol 12-myristate 13-acetate, it does not affect endothelial permeability. In porcine aortic endothelial cells, Carbazochrome reverses the formation of trypsin-induced actin stress fibers and disrupts VE-cadherin in cell monolayers. Carbazochrome(0.1-1 M) attenuated bradykinin and strombin-induced concentration-dependent [(3)H]-myo-inositol synthesis of [(3)H]-inositol. In cultured bovine vascular endothelial cells, Carbazochrome significantly inhibited the hyperpermeability induced by tryptase, thrombin and protease-activated receptor 2 agonist peptide (SLIGKV-NH(2)). Carbazochrome significantly reduced the t-PA: antigen ratio in the media in human umbilical vein endothelial cells (HUVEC), while it had no significant effect on PAI-1: antigen. |
| In vivo study | In rats, Carbazochrome(10 mg/kg) reversed ioxaglate-induced vascular hyperpermeability in a dose-dependent manner. Carbazochrome(10 mg/kg) significantly inhibited the reduction of arterial oxygen volume. |
1-METHYL-6-OXO-2,3,5,6-TETRAHYDROINDOLE-5-SEMICARBAZONO-2-SULFONIC ACID SODIUM SALT 3 HYDRATE - Reference Information
| hemostatic drug | carbazochrome sodium sulfonate is a new generation of hemostatic drug, which is a derivative of carbazochrome sodium (Anluoxue), which introduces sodium sulfonate in its molecular structure The group overcomes the shortcomings of small solubility of carbazochrome sodium and must rely on salicylic acid to assist in dissolution, so the hemostatic effect is more obvious. In addition, it does not contain salicylic acid groups, so it does not produce hemolysis, does not affect hematopoietic function, and at the same time, it has little stimulation and is safe to use; it has no adrenal function and will not cause blood pressure and heart rate fluctuations; it does not affect the coagulation mechanism. The effect is rapid and the effect is lasting. Foreign countries have been widely used to treat capillary fragility during hypertension, prevent the onset of stroke, and have hemostatic effects on pulmonary hemorrhage, gastrointestinal bleeding, and postpartum hemorrhage. At present, the drug is mainly used in China for a variety of bleeding caused by increased capillary permeability, such as urinary system, upper digestive tract, respiratory tract and obstetrics and gynecology disease bleeding. It has a significant effect on urinary system hemorrhage, and can also be used for the prevention and treatment of trauma and surgical hemorrhage, so it has been more and more widely used in clinical practice. Precautions: Do not be confused with carbacolol sodium salicylate (cardinol sodium). Cardinolol sodium cannot be administered intravenously, nor can it be used for people who are allergic to salicylate. The most commonly used hemostatic drugs are hemostatic. The main mechanisms of action are: one is to increase the number of platelets in the blood, and the other is to contract capillaries to promote the release of coagulants in platelets. However, as far as the existing hemostatic preparations are concerned, whether administered intravenously or orally, the hemostatic dosage form limits its high concentration distribution in the bleeding site tissue, thereby inhibiting hemostatic contraction of capillaries and promoting platelet release Coagulation active substance. (2016-02-01) Figure 1 is the structural formula of sodium carbazochrome sulfonate |
| combined application of sodium carbazoate and pantoprazole sodium | carbazoate sodium (carbazochromesodiumsulfonate, CSS) can reduce the permeability of capillaries, enhance the retraction of the broken end of capillaries, and can be used for various bleeding caused by increased permeability of capillaries. Pantoprazole sodium (pantoprazolesodium, PPS) is a new proton pump inhibitor, which directly acts on the proton pump in the gastric wall, specifically inhibits H and K-ATPase, can effectively inhibit gastric acid secretion, increase the pH value in the stomach, and then play a role in rapid hemostasis. Clinically, PPS and CSS are often used to treat acute upper gastrointestinal hemorrhage caused by duodenal ulcer, gastric ulcer, acute internal mucosal lesion, compound ulcer, etc. |
| biological activity | sodium Carbazochrome sulfonate is an anti-bleeding agent used to treat hemorrhoids. |
| use | blood system medicine for hemostasis |
| category | toxic substances |
| toxicity classification | low toxicity |
| acute toxicity | oral-mouse LD50:>10000 mg/kg; Intravenous-mouse LD50:>600 mg/kg |
| flammability hazard characteristics | flammability; combustion releases toxic nitrogen oxides, sodium oxide and sulfur oxide fumes |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
Last Update：2024-04-10 22:29:15
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